QUANTUM_BIOPHYSICS
Prof. Antonio Bianconi
Born: Rome, 19 dec 1944
1969 Doctor degree in Physics at University of Rome
1970-1972 Euratom-ENEA Laboratory at Frascati Italy1969-1972, researcher
1973-1975 Camerino University, Italy, Assistant Professor;and research associate at Laboratori Nazionali di Frascati, Frascati, Italy
1976-1977 Stanford University, SSRL, visiting professor andresearch associate Xerox Palo Alto Research Center, Palo Alto California
1978-1979 Camerino University, Italy, Assistant Professor
1980-1985 Rome University, Associate Professor ofExperimental Physics
1986-1991 L'Aquila University, Italy, Professor of MedicalPhysics
1987- Visiting professor Tsukuba, Photon factory, Japan
1992 -Visiting Professor, Paris VII University, France
1993-today Sapienza University of Rome, Italy, Professor ofBiophysics
His teachers have been: Gaetano Fichera, GilbertoBernardini, Edoardo Amaldi, Bruno Tusheck, Giorgio Careri; he has worked anddiscussed with Ugo Fano, Paolo Fasella, Fred Brown, Seb Doniach, Britton Chance,Maurizio Brunori, Max Perutz, John Pendry, Alex K. Müller, Hans Frauefelder etal.
Number of publications in interantional journals withreferees: 325 from 1969-today
Quantitative report from ISI Web of Science from 1991-todayneglecting publications in the 1969-1991 period:
Publications, 286
Sum of citations, 4060
Citations per item, 14.20
H-index, 33
and
H-index, 40 including the papers published in the 1969-1991period from google scholar.
He has been working in the field of biophysics since 1977starting with the first applications of XANES (x-ray absorption near edgestructure), named by him, using synchrotron radiation to the determination ofthe local structure of active sites of metalloproteins in solution.
He has contributed to several topics:
XANES of metal ions in biological membranes
XANES of calcium binding proteins: calmodulin, S100,troponin-C, parvalbumin
Active site structure of hemoglobin, myoglobin,
Ligand binding angle in emoproteins in solution and crystal
Polarized X-ray absorption of proteins
Local Fe structure modulation in the rransition between T-Rconformations in hemoglobin
Effect of allosteric effectors in hemoglobin conformations
Cu K.edge XANES investigations of Hemocyanins
Structure-function relationship in the serotransferrin
Determination of the first intemediate state of CO inphotodissociated carbonmonoxy myoglobin
Modulation of active sites in mutant myoglobin
The site structure modulation and function of tyrosinase insolution
The conformations landscape of the active site in myoglobinin the denaturation process
The introduction of TDXAS temperature dependent x-rayabsorption spectroscopy for determination of the conformation landscape ofcarbonmonoxymyoglobin
The possible role of Feshbach resonances in biomolecularassociation and dissociation processes for evading quantum decoherence inliving matter.
Selected pubblicationsin Biophysics
[1] The Emergence of Life in theUniverse at the Epoch of Dark Energy Domination Nicola Poccia,Alessandro Ricci, Antonio Bianconi, Journal of Cosmology, 5, 875-882, (2010 ).
[2] A Possible Mechanism forEvading Temperature Quantum Decoherence in Living Matter by Feshbach Resonance Nicola Poccia,Alessandro Ricci, Davide Innocenti and Antonio Bianconi Int. J. Mol. Sci. 2009, 10(5), 2084-2106;doi:10.3390/ijms10052084 (special issue on the origin of life)". http://www.mdpi.com/1422-0067/10/5/2084
[3] TDXAS study of theconformational landscape of MbCO. A. Bianconi, F. Natali, M. L. Alosi, S. Grande,A. Lanzara, N. L. Saini, and M. Brunelli, Journal of synchrotron radiation 6, 389 (1999), ISSN0909-0495, URL http://dx.doi.org/10.1107/S0909049598017063.
[4] Light induced states in MbCOdenatured with guanidine hydrochloride. F. Natali, L. Moretti, F. Boffi, A. Bianconi,S. Della Longa, and A. Congiu Castellano, European biophysics journal : EBJ 27, 1 (1998), ISSN0175-7571, URL http://view.ncbi.nlm.nih.gov/pubmed/9463885.
[5] Spin-resolved X-ray absorption near edge structure(XANES) simulation of metmyoglobin. S. Della Longa, M. Girasole, A. CongiuCastellano, A. Bianconi, A. P. Kovtun, and A. V. Soldatov, European BiophysicsJournal 27,541 (1998), ISSN 0175-7571, URL http://dx.doi.org/10.1007/s002490050164.
[6] Aluminum site structure inserum transferrin and lactoferrin revealed by synchrotron radiation X-ray spectroscopy. A. Congiu-Castellano, F. Boffi, S. Della Longa, A.Giovannelli, M. Girasole, F. Natali, M. Pompa, A. Soldatov, and A. Bianconi,Biometals : an international journal on the role of metal ions in biology,biochemistry, and medicine 10, 363 (1997), ISSN 0966-0844, URL http://view.ncbi.nlm.nih.gov/pubmed/9353887.
[7] The dinuclear copper site structure of Agaricusbisporus tyrosinase in solution probed by X-ray absorption spectroscopy. S. Della Longa, I.Ascone, A. Bianconi, A. Bonfigli, A. Congiu-Castellano, O. Zarivi, and M.Miranda, The Journal of biological chemistry 271, 21025 (1996), ISSN0021-9258, URL http://dx.doi.org/10.1074/jbc.271.35.21025.
[8] Ironsite structure of two irreversible hemichromes from human hemoglobin, untreatedand oxidized to sulfoxide at MetD6(55)beta. S. Della Longa, G. Amiconi, O. ArtanSalah, I. Ascone, M. Barteri, A. Bertollini, A. Bianconi, and A. CongiuCastellano, Biochimica et biophysica acta 1294, 72 (1996), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/8639716
[9] Conformationalstates of hemoproteins by XANES: The mutant VR myoglobin S. Della-Longa, A. Bianconi, A.Brancaccio, M. Brunori, A. Congiu-Castellano, F. Cutruzzolā, J. L. Hazemann, M.Missori, and C. Travaglini-Allocatelli, Physica B: Condensed Matter 208-209, 743 (1995),ISSN 09214526, URL http://dx.doi.org/10.1016/0921-4526(94)01020-2.
[10] Intermediate states inligand photodissociation of carboxymyoglobin studies by dispersive X-rayabsorptionD. Della Longa S, I. Ascone, A. Fontaine, A. Congiu Castellano, and A.Bianconi, European biophysics journal : EBJ 23, 361 (1994), ISSN 0175-7571, URL http://view.ncbi.nlm.nih.gov/pubmed/7835320.
[11] Structure-functionrelationship in the serotransferrin: the role of the pH on the conformationalchange and the metal ions release. A. Congiu Castellano, M. Barteri, M. Castagnola,A. Bianconi, E. Borghi, and S. Della Longa, Biochemical and biophysicalresearch communications 198, 646 (1994), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/8297375.
[12] An x-ray absorption nearedge structure spectroscopy study of metal coordination in Co(II)-substitutedCarcinus maenas hemocyanin. S. Della Longa, A. Bianconi, L. Palladino, B. Simonelli, A.Congiu Castellano, E. Borghi, M. Barteri, M. Beltramini, G. P. Rocco, and B.Salvato, Biophysical journal 65, 2680 (1993), ISSN 0006-3495, URL http://dx.doi.org/10.1016/S0006-3495(93)81330-4.
[13] Hemoglobins XAS Spectroscopy S. Pin, B. Alpert, A.Congiu Castellano, S. Della Longa, and A. Bianconi in Hemoglobins of the seriesMethods in Enzymology Part C Biophysical Methods edited by J. Everse, Kim D.Vandegriff, R. M. Winslow Academic Press, inc. San Diego California 1994 vol.232 pag. 266-292 ISBN-13: 978-0121821333 http://www.amazon.com/Hemoglobins-Part-Biophysical-Methods-Enzymology/dp/0121821331
[14] X-ray small angle scatteringof the human transferrin protein aggregates. A fractal study. A. Congiu-Castellano, M.Barteri, A. Bianconi, E. Borghi, L. Cassiano, M. Castagnola, and S. Dellalonga,Biophysical journal 64,520 (1993), ISSN 0006-3495, URL http://dx.doi.org/10.1016/S0006-3495(93)81394-8.
[15] Influence of allostericeffectors on the heme conformation of dromedary ferrous nitrosylhemoglobindetected by XANES spectroscopy. A. Congiu Castellano, S. Della Longa, A.Bianconi, M. Barteri, E. Burattini, P. Ascenzi, M. Coletta, R. Santucci, and G.Amiconi, Biochimica et biophysica acta 1080, 119 (1991), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/1932085.
[16] Heterogeneity of theisolated subunits of the fetal and adult human hemoglobin in solution, detectedby XANES spectroscopy. A. Congiu Castellano, M. Castagnola, E. Burattini, M. Dell'Ariccia,S. Della Longa, A. Giovannelli, P. J. Durham, and A. Bianconi, Biochimica etbiophysica acta 996,240 (1989), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/2473782.
[17] Influence of globinstructure on the heme in dromedary carbonmonoxyhemoglobin. G. Amiconi, R. Santucci,M. Coletta, A. C. Castellano, A. Giovannelli, M. Dell'Ariccia, S. Della Longa,M. Barteri, E. Burattini, and A. Bianconi, Biochemistry 28, 8547 (1989), ISSN0006-2960, URL http://view.ncbi.nlm.nih.gov/pubmed/2605205.
[18] Linear Fe-C-O configuration in carbonyl1-methylimidazole iron(II) porphyrin detected by XANES in dispersive mode. I. Ascone, A. Bianconi,E. Dartyge, S. Della Longa, A. Fontaine, and M. Momenteau, Biochimica etbiophysica acta915, 168 (1987), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/3651469.
[19] Oxygen bonding in humanhemoglobin and its isolated subunits: a XANES study. A. Congiu-Castellano, A.Bianconi, M. Dell'Ariccia, S. Della Longa, A. Giovannelli, E. Burattini, and M.Castagnola, Biochemical and biophysical research communications 147, 31 (1987), ISSN0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/2443133.
[20] Local Fe site structure inthe tense-to-relaxed transition in carp deoxyhemoglobin: a XANES (x-rayabsorption near edge structure) study. A. Bianconi, A. Congiu-Castellano, M.Dell'Ariccia, A. Giovannelli, S. Morante, E. Burattini, and P. J. Durham, Proceedingsof the National Academy of Sciences of the United States of America 83, 7736(1986), ISSN 0027-8424, URL http://view.ncbi.nlm.nih.gov/pubmed/3463997.
[21] The CO bond angle ofcarboxymyoglobin determined by angular-resolved XANES spectroscopy A. Bianconi, A.Congiu-Castellano, P. J. Durham, S. S. Hasnain, and S. Phillips, Nature 318, 685 (1985), ISSN0028-0836, URL http://view.ncbi.nlm.nih.gov/pubmed/4079982.
[22] Increase of the Fe effective chargein hemoproteins during oxygenation process. A. Bianconi, A.Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, and P. J.Durham, Biochemical and biophysical research communications 131, 98 (1985), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/4038310.
[23] Constraints of T conformation ofcarp azide hemoglobin on Fe site structure. A. Bianconi, A.Congiu-Castellano, M. L'Ariccia, A. Giovannelli, and S. Morante, FEBSletters 191, 241 (1985), ISSN 0014-5793.
[24] Changes in Fe site structurefrom fetal to adult hemoglobin probed by XANES. A. Bianconi, A.Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, M.Castagnola, and P. J. Durham, Biochimica et biophysica acta 831, 120 (1985), ISSN0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/2412587.
[25] Determination of CO and CNbond angles by X-ray absorption edge structure in chelated protoheme insolutionA. Bianconi A. Congiu-Castellano, M. Dell'ariccia, A. Giovannelli, E.Burattini, P.J. Durham, G.M. Giacometti, S. Morante Biochimica et BiophysicaActa831,114-119 (1985)
[26] Increase of the Fe effectivecharge in hemoproteins during oxygenation process A. Bianconi, A.Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, and P. J. Durham,Biochemical and biophysical research communications 131, 98 (1985), ISSN0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/4038310.
[27] XANES study of irondisplacement in the haem of myoglobin. A. Bianconi, A.Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, P. J. Durham, E. Burattini,and M. Barteri, FEBS letters 178, 165(1984), ISSN 0014-5793, URL http://view.ncbi.nlm.nih.gov/pubmed/6500058.
[28] X ray absorption near edgestructure (XANES) for CO, CN and deoxy hemoglobin: geometrical information P. Durham, A. Bianconi, A. Congiu-Castellano, A.Giovannelli, S. S. Hasnain, L. Incoccia, S. Morante, and J. B. Pendry, TheEMBO journal2, 1441 (1983), ISSN 0261-4189, URL http://view.ncbi.nlm.nih.gov/pubmed/11892793.
[29] XANESDetermination of calcium sites of troponin-C and parvalbumin A. Bianconi, A.Giovannelli, L. Castellani, S. Alema, P. Fasella, B. Oesch, and S. Mobilio, Journalof molecular biology165, 125 (1983), ISSN 0022-2836, URL http://view.ncbi.nlm.nih.gov/pubmed/6842603.
[30] X-ray absorption spectroscopy (EXAFS and XANES) astructural tool for calcium binding proteins: effect of Mg2+ on Ca2+ bindingsites of troponin-C,S. Alemā, A. Bianconi, L. Castellani, and P. Fasella, Progress in clinicaland biological research 102 Pt C, 47 (1982), ISSN 0361-7742, URL http://view.ncbi.nlm.nih.gov/pubmed/7167467.
[31] X-ray absorption near edgestructure determination of calcium sites of troponin C and parvalbumin. A. Bianconi, S. Alema,L. Castellani, P. Fasella, A. Giovannelli, S. Mobilio, and B. Oesch, Actaradiologica. Supplementum 365, 27 (1983), ISSN 0365-5954. URL http://view.ncbi.nlm.nih.gov/pubmed/6591728.
[32] Determination of the Ca sitestructure in the S 100 protein by using synchrotron radiation. Bianconi, A., Biocca,S., L. Castellani, L., Fasella, P., Comin F. und Mobilio S., Ital. J.Biochem.,29 (1); 7173, (1980)
[33] Structure of the calciumbinding sites in troponin-C and calmodulin studied by EXAFS A. Bianconi, B. Oesh,S. Alemā, L. Castellani, I. Davoli, P. Fasella and S. Mobilio in Caciumbinding proteins: Structure and function edited by F. L. Siegel et al. ElsevierNorth Holland, Amsterdam, pag. 297 (1980)
[34] Correlation ofk-absorption edge and exafs spectra of human ferric transferrin with thosemodel iron(iii) complexes L. Alagna, A. A. G. Tomlinson, A. Bianconi, and A. Desideri,Inorganica Chimica Acta 40, X72+ (1980), ISSN 00201693, URL http://dx.doi.org/10.1016/S0020-1693(00)92141-8.
[35] X-ray Ca K edge ofCalcium-Adenosine triphosphate system and of simple calcium Compounds A. Bianconi, S.Doniach, and D. Lublin, Chemical Physics Letters 59, 121 (1978), ISSN00092614, URL http://dx.doi.org/10.1016/0009-2614(78)85629-2.
[36] Biophysics and SynchrotronRadiation edited by A.Bianconi and A. Congiu Castellano, Springer Series in Biophysics vol. 2 Springer Verlag, Berlin 1987
[37] XANES of Condensed Systemsby A. Bianconi, J. Garcia, and M. Benfatto in Synchrotron Radiation inChemistry and Biology I (Topics in CurrentChemistry Vol. 145) by E. Mandelkow pp. 29-67 (1988) Spriger Verlag, Berlin1988
He has introduced new physical experimental methods andconcepts:
XEOL: x-ray emission optical luminescence;
XANES: x-ray absorption near edge structure, due to multiplescattering resonances for detecting high order correlation function of thelocal structure in complex systems:
SUPERSTRIPES: heterostructures at atomic limit where thequantum mechansm for evading temperature decoherence effects appears by tuningthe chemecal potential.
Moreover he has been working in:
Liquid helium film
Photon-surface plasmon wave transformation
Photoemission spectroscopy of complex disordered systemssince 1975
Synchrotron radiation research since 1972
Core excitons in synchrotron radiation absorptionspectroscopy
Shape resonances in synchrotron radiation absorptionspectroscopy
Multiple scattering resonances in XANES of complex systems
Ions in solution.
Catalists
Surfaces and interfaces
Correlated electronic systems
Valence fluctuation systems
High temperature superconductors